Karadeli, UmitCicekliyurt, Meliha M.2026-07-182026-07-182026-07-141314-6246https://editorial.uni-plovdiv.bg/index.php/JBB/article/view/642https://doi.uni-plovdiv.bg/handle/store/1049Kidney transplantation remains the best method for kidney failure. However, ischemia-reperfusion injury (I/R) is one of the main problems in graft survival. The University of Wisconsin (UW) solution, which made history with great hope, has shown its protective effect, but coping with oxidative stress is not easy. Ozone, which is frequently used in alternative medicine, has been studied as a potential adjunctive strategy in solid organ transplantation, particularly to improve organ preservation and reduce ischemia-induced damage. This review summarizes the current experimental and translational evidence regarding the potential role of ozone therapy in organ protection, organ transplantation, and the regulation of oxidative stress. Examples of transplantation and clinical applications are provided, highlighting the effects of ozone.enKidney transplantationOksidative stressOzone therapyUWArticle