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Digital library of scientific journals published by Plovdiv University Paisii Hilendarski.

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Browsing Journals by Author "Abdullahi, Zayyanu"

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    Analgesic effect of ethylacetate fraction of the methanol leaf extract of Hannoa klaineana in rats
    (Plovdiv University Press “Paisii Hilendarski”, 2025-01-10) Abubakar, Ibrahim; Gusau, Mu’azu Abubakar; Danyaya, Jabir Aliyu; Ibrahim, Shehu; Abdullahi, Zayyanu; Zubairu, Abdulhakim; Sahabi, Abdulsalam Umar
    Pain remains a major health, social, and economic problem worldwide. Hannoa klaineana Pierre & Engl. is a medicinal plant found in many African countries and used for the treatment of many diseases including pain-associated disorders. This study was conducted to evaluate the analgesic effect of the ethylacetate fraction of methanol leaf extract of Hannoa klaineana in rats. The analgesic effect of the ethylacetate fraction of methanol leaves extract of Hannoa klaineana (200, 400, and 600 mg/kg b.wt) was evaluated using acetic acid-induced writhing, tail flick (immersion), and hot plate model. In the acetic acid-induced writhing test, the extract (200, 400, and 600 mg/kg) demonstrated a significant (p < 0.05) decrease in the number of writhes with maximum percentage inhibition (75.61%) at 600 mg/kg dose of the extract. In tail flick and hot plate tests, the extract (200, 400, and 600 mg/kg b.wt) exhibited a significant (p < 0.05) increase in rats’ response with a steady increase in reaction time. Findings from this study show that ethylacetate fraction of the methanol leaves extract of Hannoa klaineana possessed analgesic activity which provided justification for the local use of the plant in the treatment of pain.