Acetylcholinesterase inhibitory, antioxidant, and antimicrobial activities of Salvia tomentosa Mill. essential oil

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dc.contributor.authorMarchev, Andrey
dc.contributor.authorIvanov, Ivan
dc.contributor.authorDenev, Petko
dc.contributor.authorNikolova, Milena
dc.contributor.authorGochev, Velizar
dc.contributor.authorStoyanova, Albena
dc.contributor.authorPavlov, Atanas
dc.contributor.authorGeorgiev, Vasil
dc.date.accessioned2024-05-28T19:40:46Z
dc.date.available2024-05-28T19:40:46Z
dc.date.issued2015-08-10
dc.description.abstractChemical composition and bioactivity of essential oil from Salvia tomentosa Mill. natively grown in Bulgaria were investigated. GC-MS analysis identified 60 compounds which represented 98% of the oil constituents. The prevalent constituents were monoterpenes with eight dominant compounds being identified: borneol (10.3%), β-pinene (9%), camphor (7.9%), α-pinene (6%), camphene (4%), 1.8-cineole (3.8%), α-limonene (3.5%) and β-caryophyllene (3%). The essential oil showed considerable acetylcholinesterase inhibitory activity (IC50=0.28±0.06 μg/mL), comparable with that of galanthamine. Study of antioxidant activity strongly suggested that the hydrogen atom transfer reaction was preferable over the electron transfer (ORAC=175.0±0.40 μM Trolox equivalents/g oil and FRAP=1.45±0.21 mM Trolox equivalents/g oil). The essential oil showed moderate antifungal and antibacterial activities against Candida albicans and Gram-positive bacteria, whereas it was almost inactive against the investigated Gram-negative strains. The results suggested that the essential oil of Bulgarian S. tomentosa could be considered as a prospective active ingredient for prevention of oxidative stress-related and neurodegenerative disorders in aromatherapy. Because of the high antioxidant capacity, the oil could be considered as natural supplement or antioxidant in cosmetics and food products.
dc.identifier.issn1314-6246
dc.identifier.urihttps://doi.uni-plovdiv.bg/handle/store/137
dc.language.isoen
dc.publisherPlovdiv University Press “Paisii Hilendarski”
dc.subjectBalsamic sage
dc.subjectantibacterial
dc.subjectaromatherapy
dc.subjectanti-acetylcholinesterase
dc.titleAcetylcholinesterase inhibitory, antioxidant, and antimicrobial activities of Salvia tomentosa Mill. essential oil
dc.typeArticle
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