Synergistic Effect of Meropenem and Vancomycin Antibiotics with Ecballium elaterium and Senna italica Extracts

Simple item page
dc.contributor.authorAbdallah, Lubna
dc.contributor.authorOdeh, Hiba
dc.contributor.authorSalem, Huda
dc.contributor.authorBarham, Thanaa
dc.contributor.authorNazzal, Samah
dc.contributor.authorKokaly, Rahaf
dc.contributor.authorAldeen, Hana Sa’d
dc.contributor.authorHoluo, Amal
dc.date.accessioned2025-01-28T06:51:39Z
dc.date.available2025-01-28T06:51:39Z
dc.date.issued2025-01-10
dc.description.abstractThe aim of this study is to determine whether the use of plant extracts like Ecballium elaterium and Senna italica leaf aqueous extracts helps support the activity of meropenem and vancomycin antibiotics against Staphylococcus aureus and Staphylococcus epidermis bacteria. The minimum inhibitory concentration (MIC) and the fractional inhibitory concentration (FIC) were used to find out the antibacterial effect of E. elaterium and S. italica extracts in combination with meropenem and vancomycin antibiotics by employing microbroth dilution assay and checkerboard assay. According to the obtained results, all combinations showed a synergistic effect against S. aureus except vancomycin and S. italica combinations which exhibited an additive effect. Moreover, all combinations exhibited an additive effect against S. epidermis except vancomycin and E. elatenium, which showed a synergistic effect. In conclusion, E. elaterium and S. italica leaf aqueous extracts have great potential as sources of antibacterial compounds against microorganisms and they can be used to treat infectious diseases caused by antibiotic-resistant microorganisms.
dc.identifier.issn1314-6246
dc.identifier.urihttps://doi.uni-plovdiv.bg/handle/store/561
dc.language.isoen
dc.publisherPlovdiv University Press “Paisii Hilendarski”
dc.subjectEcballium elaterium
dc.subjectSenna italica
dc.subjectSynergy
dc.subjectMeropenem
dc.subjectVancomycin
dc.subjectAntibiotics
dc.titleSynergistic Effect of Meropenem and Vancomycin Antibiotics with Ecballium elaterium and Senna italica Extracts
dc.typeArticle
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
jbb20242173.pdf
Size:
309.91 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
73 B
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
Journal of BioScience and Biotechnology (JBB)