Myostatin gene (MSTN) polymorphism with a negative effect on meat productivity in Dzhalginsky Merino sheep breed

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dc.contributor.authorTrukhachev, Vladimir
dc.contributor.authorBelyaev, Valery
dc.contributor.authorKvochko, Andrey
dc.contributor.authorKulichenko, Alexander
dc.contributor.authorKovalev, Dmitry
dc.contributor.authorPisarenko, Sergey
dc.contributor.authorVolynkina, Anna
dc.contributor.authorSelionova, Marina
dc.contributor.authorAybazov, Magomet
dc.contributor.authorShumaenko, Svetlana
dc.contributor.authorOmarov, Arslan
dc.contributor.authorMamontova, Tatyana
dc.contributor.authorGolovanova, Natalia
dc.contributor.authorYatsyk, Olesya
dc.contributor.authorKrivoruchko, Alexander
dc.date.accessioned2024-05-28T19:30:19Z
dc.date.available2024-05-28T19:30:19Z
dc.date.issued2015-08-03
dc.description.abstractOne of the most important negative regulator of muscle grow in mammalians is myostatin. Some mutations in myostatin gene (MSTN) can decrease the effect of protein and play role in meat quality of sheep. Therefore, in genome selection, knowledge of MSTN gene structure is very important. We investigated the polymorphism of the MSTN gene and its influence on body parameters in Russian sheep breed Dzhalginsky Merino. To detect alleles, we use NimbleGen sequencing technolog). In this breed, we found 20 single nucleotide polymorphism (SNP). That is SNP in promoter: с.-1866, с.-1404, с.-1401, с.-1213, с.-1128, с.-958, с.-783; 5'UTR: с.-40; exon I: с.101; intron 1-2: c.373+18, c.373+241, c.373+243, c.373+259, c.373+563; intron 2-3: с.747+164, с.747+309, с.748-810, с.748-229G>A, с.748-475; 3'UTR: с.*1232. Three of detected SNP (c.-1128, c.-958, c.-40) have a negative effect on the body parameters – decrease weight, height and other. Other three SNP (c.101, c.373+18, с.*1232) have not significant influence on this parameters. Our investigation is a base of next research of affection of different MSTN gene alleles on meat quality and can be used to prepare a PCR test-system for genomic selection.
dc.identifier.issn1314-6246
dc.identifier.urihttps://doi.uni-plovdiv.bg/handle/store/134
dc.language.isoen
dc.publisherPlovdiv University Press “Paisii Hilendarski”
dc.subjectMyostatin
dc.subjectMSTN
dc.subjectSheep
dc.subjectDzhalginsky Merino
dc.subjectSNP
dc.subjectSequence
dc.titleMyostatin gene (MSTN) polymorphism with a negative effect on meat productivity in Dzhalginsky Merino sheep breed
dc.typeArticle
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