Production of cyanobacterial toxins from two Nostoc species (Nostocales) and evaluation of their cytotoxicity in vitro

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dc.contributor.authorTeneva, Ivanka
dc.contributor.authorStoyanov, Plamen
dc.contributor.authorBelkinova, Detelina
dc.contributor.authorDimitrova-Dyulgerova, Ivanka
dc.contributor.authorMladenov, Rumen
dc.contributor.authorDzhambazov, Balik
dc.date.accessioned2024-05-22T17:19:07Z
dc.date.available2024-05-22T17:19:07Z
dc.date.issued2012-05-12
dc.description.abstractCyanobacteria are among the oldest autotrophic organisms with cosmopolitan distribution and known as producers of secondary metabolites with toxic properties named “cyanotoxins”. Studies with respect to toxin production of genus Nostoc are yet limited. In the present study we have investigated two Nostoc species (Nostoc linckia and Nostoc punctiforme) for production of intracellular and/or extracellular compounds with cytotoxic potential. Extracts and algal growth media were assessed by different in vitro tests using freshly established mouse primary cultures from different tissues and one fish cell line. Our data showed that the mouse cells are more sensitive to toxic compounds than the fish cells. Both Nostoc species produced intracellular and extracellular bioactive compounds with different effects on mouse and fish cells. The presence of cyanotoxins as anatoxin-a and microcystins/nodularin was confirmed by HPLC and ELISA analyses. Therefore, Nostoc species are not only sources of bioactive compounds with therapeutic action, but they can be a potential hazard to aquatic systems as well as to animal and human health.
dc.identifier.citationTeneva I., Stoyanov P., Belkinova D., Dimitrova-Dyulgerova I., Mladenov R., Dzhambazov B. 2012. Production of cyanobacterial toxins from two Nostoc species (Nostocales) and evaluation of their cytotoxicity in vitro. – Journal of BioScience and Biotechnology, 1(1): 33-43.
dc.identifier.issn1314-6246
dc.identifier.urihttps://doi.uni-plovdiv.bg/handle/store/12
dc.language.isoen
dc.publisherPlovdiv University Press "Paisii Hilendarski"
dc.subjectCyanobacteria
dc.subjectNostoc
dc.subjectcytotoxicity
dc.subjectin vitro
dc.subjecttoxins
dc.titleProduction of cyanobacterial toxins from two Nostoc species (Nostocales) and evaluation of their cytotoxicity in vitro
dc.typeArticle
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